细菌RNA聚合酶：完整的故事。

Bacterial RNA polymerases: the wholo story.

作者信息

Murakami Katsuhiko S, Darst Seth A

机构信息

The Rockefeller University, Box 224, 1230 York Avenue, New York, NY 10021, USA.

出版信息

Curr Opin Struct Biol. 2003 Feb;13(1):31-9. doi: 10.1016/s0959-440x(02)00005-2.

DOI:10.1016/s0959-440x(02)00005-2

PMID:12581657

Abstract

Recent structural and biophysical results have provided unprecedented insights into the structure and function of the bacterial RNA polymerase holoenzyme as it goes through the steps of transcription initiation. Comparisons with structural analyses of evolutionarily unrelated RNA polymerases reveal unexpected general features of the initiation process.

摘要

最近的结构和生物物理研究结果，为细菌RNA聚合酶全酶在转录起始过程中的结构和功能提供了前所未有的见解。与进化上无关的RNA聚合酶的结构分析进行比较，揭示了起始过程中意想不到的一般特征。