Giovannucci Edward, Pollak Michael, Liu Yan, Platz Elizabeth A, Majeed Noreen, Rimm Eric B, Willett Walter C
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):84-9.
The insulin-like growth factor (IGF) axis may play opposing roles in health and disease. The age-related declines in growth hormone and IGF-I may be associated with potentially deleterious changes in body composition and functioning, but recent studies suggest that IGF-I levels may be related to risk of prostate, colorectal, premenopausal breast, and possibly other cancers. Thus, we studied dietary influences on plasma IGF-I and IGF-I:IGF-binding protein-3 ratio in 753 men in the Health Professionals Follow-Up Study who completed a food frequency questionnaire. In this generally well-nourished population of middle-aged to elderly men, plasma IGF-I and IGF-I:IGF-binding protein-3 molar ratio tended to increase with higher intake of protein and minerals, including potassium, zinc, magnesium, calcium, and phosphorus. Men with relatively high intakes of total protein (top quintile) and minerals (top quintile of the five minerals combined) had a 25% higher mean plasma level of IGF-I compared with those in the low quintiles simultaneously. The major sources of animal protein, including milk, fish, and poultry, but not red meat, as well as total vegetable protein, were associated with an increase in IGF-I levels. Energy intake was positively related to plasma IGF-I level but only in men with body mass index <25 kg/m(2). The age-related decline in plasma IGF-I may be exacerbated by low intakes of protein and minerals. The potential role of these dietary factors on cancer risk through altering IGF-I levels requires study.
胰岛素样生长因子（IGF）轴在健康和疾病中可能发挥相反的作用。生长激素和IGF-I随年龄增长而下降，这可能与身体成分和功能的潜在有害变化有关，但最近的研究表明，IGF-I水平可能与前列腺癌、结直肠癌、绝经前乳腺癌以及其他可能的癌症风险有关。因此，在健康专业人员随访研究中，我们对753名完成食物频率问卷调查的男性进行了饮食对血浆IGF-I及IGF-I与IGF结合蛋白-3比值影响的研究。在这个总体营养良好的中年至老年男性人群中，血浆IGF-I及IGF-I与IGF结合蛋白-3的摩尔比往往会随着蛋白质和矿物质摄入量的增加而升高，这些矿物质包括钾、锌、镁、钙和磷。与同时处于低五分位数的男性相比，总蛋白摄入量相对较高（最高五分位数）和矿物质摄入量相对较高（五种矿物质合计的最高五分位数）的男性，其血浆IGF-I平均水平高出25%。动物蛋白的主要来源，包括牛奶、鱼类和家禽，但不包括红肉，以及总植物蛋白，均与IGF-I水平升高有关。能量摄入与血浆IGF-I水平呈正相关，但仅在体重指数<25kg/m²的男性中如此。蛋白质和矿物质摄入不足可能会加剧血浆IGF-I随年龄增长而下降的情况。这些饮食因素通过改变IGF-I水平对癌症风险的潜在作用有待研究。
