Lew Wook, Lim Ha Seong, Kim You Chan
Departments of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
J Am Acad Dermatol. 2003 Feb;48(2 Suppl):S39-40. doi: 10.1067/mjd.2003.113.
Malignant fibrous histiocytoma is the most common soft tissue sarcoma, but cutaneous metastasis of this tumor is quite rare. A 30-year-old female patient had several brownish 0.5 x 0.5-cm papules on her right ankle. Histopathologic examination revealed spindle-shaped tumor cells with cellular pleomorphism and high mitosis (5 of 10 high-power fields), suggestive of malignant fibrous histiocytoma. She had a history of left subcutaneous breast mass that was diagnosed as malignant fibrous histiocytoma 3 years earlier. We report a case of malignant fibrous histiocytoma with pleomorphism mixed with spindle-shaped cells and multinuclear giant cells, which metastasized to the skin.
恶性纤维组织细胞瘤是最常见的软组织肉瘤,但该肿瘤的皮肤转移相当罕见。一名30岁女性患者右踝部有几个0.5×0.5厘米的褐色丘疹。组织病理学检查显示梭形肿瘤细胞,具有细胞多形性和高有丝分裂象(10个高倍视野中有5个),提示为恶性纤维组织细胞瘤。她有左侧乳腺皮下肿块病史,3年前被诊断为恶性纤维组织细胞瘤。我们报告一例具有多形性、混合梭形细胞和多核巨细胞的恶性纤维组织细胞瘤,其发生了皮肤转移。