Wu Wanying, Li Yungu
College of Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102.
Zhong Yao Cai. 2002 Apr;25(4):282-4.
To compare the distribution of genistein chitosan microsphere capsule (M.C) in vivo in rats with that of genistein common capsule (C.C). To research slow-released target microsphere capsule.
The study on pharmacokinetics of M.C and C.C were analyzed by HPLC and 3P97 software.
The concentration of M.C distributed among various organs decreased slower than those of C.C and were able to keep a certain concentration for a long time. Genistein common capsule mainly distributed in livers of rats, while genistein chitosan microsphere capsule distributed mainly in lungs and spleens of rats.
The chitosan microsphere capsule of genistein has better slow-release and has tendency to distribute in lungs and spleens.
比较金雀异黄素壳聚糖微球胶囊（M.C）与金雀异黄素普通胶囊（C.C）在大鼠体内的分布情况。研究缓释靶向微球胶囊。
采用高效液相色谱法和3P97软件分析M.C和C.C的药代动力学。
M.C在各器官中的分布浓度下降速度比C.C慢，且能长时间保持一定浓度。金雀异黄素普通胶囊主要分布于大鼠肝脏，而金雀异黄素壳聚糖微球胶囊主要分布于大鼠肺脏和脾脏。
金雀异黄素壳聚糖微球胶囊具有较好的缓释性能，且有在肺脏和脾脏分布的倾向。
