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[青藤碱对吗啡依赖大鼠戒断症状及神经递质的影响]

[Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats].

作者信息

Wang Caiyun, Mo Zhixian, Zhu Qiushuang, Wen Lei

机构信息

First Military Medical University, Guangzhou 510515.

出版信息

Zhong Yao Cai. 2002 May;25(5):337-9.

PMID:12583191
Abstract

OBJECTIVE

To study on the detoxification effect of sinamine in morphine-dependent rats.

METHODS

Morphine-dependent rats were induced by injecting morphine on dosage increasing by degrees, then treated with medication. The withdrawal symptoms, body weight and NE, DA, 5-HT in the brain were tested.

RESULTS

Sinamine could alleviate withdrawal symptom, reablement body weight, inhibit neurotransmitter in the brain.

CONCLUSION

Sinamine have effects on morphine-dependent rats which may relate to modulating neurotransmitter.

摘要

目的

研究青藤碱对吗啡依赖大鼠的脱毒作用。

方法

采用递增剂量注射吗啡的方法诱导吗啡依赖大鼠，然后进行药物治疗。检测大鼠的戒断症状、体重以及脑内去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5-HT）的含量。

结果

青藤碱可减轻戒断症状，恢复体重，抑制脑内神经递质。

结论

青藤碱对吗啡依赖大鼠有作用，可能与调节神经递质有关。

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[Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats].[青藤碱对吗啡依赖大鼠戒断症状及神经递质的影响]
Zhong Yao Cai. 2002 May;25(5):337-9.
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[Study on the detoxification of alcohol extracts from orientvine and its effective component on withdrawal syndromes of morphine].[东莨菪碱醇提取物及其有效成分对吗啡戒断综合征脱毒作用的研究]
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[Immunization with neuromediators (serotonin, dopamine, noradrenaline) conjugated with a protein suppresses the morphine abstinence syndrome].用与蛋白质结合的神经介质（血清素、多巴胺、去甲肾上腺素）进行免疫接种可抑制吗啡戒断综合征。
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与可乐定相比，强迫运动对吗啡戒断症状、血皮质醇和血糖水平的减轻作用。
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