[青藤碱对吗啡依赖大鼠戒断症状及神经递质的影响]
[Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats].
作者信息
Wang Caiyun, Mo Zhixian, Zhu Qiushuang, Wen Lei
机构信息
First Military Medical University, Guangzhou 510515.
出版信息
Zhong Yao Cai. 2002 May;25(5):337-9.
OBJECTIVE
To study on the detoxification effect of sinamine in morphine-dependent rats.
METHODS
Morphine-dependent rats were induced by injecting morphine on dosage increasing by degrees, then treated with medication. The withdrawal symptoms, body weight and NE, DA, 5-HT in the brain were tested.
RESULTS
Sinamine could alleviate withdrawal symptom, reablement body weight, inhibit neurotransmitter in the brain.
CONCLUSION
Sinamine have effects on morphine-dependent rats which may relate to modulating neurotransmitter.
目的
研究青藤碱对吗啡依赖大鼠的脱毒作用。
方法
采用递增剂量注射吗啡的方法诱导吗啡依赖大鼠，然后进行药物治疗。检测大鼠的戒断症状、体重以及脑内去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5-HT）的含量。
结果
青藤碱可减轻戒断症状，恢复体重，抑制脑内神经递质。
结论
青藤碱对吗啡依赖大鼠有作用，可能与调节神经递质有关。
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