IslandPath：协助检测原核生物中的基因组岛。

IslandPath: aiding detection of genomic islands in prokaryotes.

作者信息

Hsiao William, Wan Ivan, Jones Steven J, Brinkman Fiona S L

机构信息

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6.

出版信息

Bioinformatics. 2003 Feb 12;19(3):418-20. doi: 10.1093/bioinformatics/btg004.

DOI:10.1093/bioinformatics/btg004

PMID:12584130

Abstract

UNLABELLED

Genomic islands (clusters of genes of potential horizontal origin in a prokaryotic genome) are frequently associated with a particular adaptation of a microbe that is of medical, agricultural or environmental importance, such as antibiotic resistance, pathogen virulence, or metal resistance. While many sequence features associated with such islands have been adopted separately in applications for analysis of genomic islands, including pathogenicity islands, there is no single application that integrates multiple features for island detection. IslandPath is a network service which incorporates multiple DNA signals and genome annotation features into a graphical display of a bacterial or archaeal genome, to aid the detection of genomic islands.

AVAILABILITY

This application is available at http://www.pathogenomics.sfu.ca/islandpath and the source code is freely available, under GNU public licence, from the authors.

SUPPLEMENTARY INFORMATION

An online help file, which includes analyses of the utility of IslandPath, can be found at http://www.pathogenomics.sfu.ca/islandpath/current/islandhelp.html

摘要

未标注

基因组岛（原核生物基因组中潜在水平来源的基因簇）通常与具有医学、农业或环境重要性的微生物的特定适应性相关，如抗生素抗性、病原体毒力或金属抗性。虽然与这类岛相关的许多序列特征已分别应用于基因组岛分析，包括致病岛，但没有一个单一的应用程序能整合多种特征来检测岛。IslandPath是一项网络服务，它将多种DNA信号和基因组注释特征整合到细菌或古菌基因组的图形显示中，以辅助基因组岛的检测。