Kotel'nikov V M, Arkhangel'skiĭ V V, Safronov V A
Vopr Neirokhir. 1976 Jan-Feb(1):36-41.
The thymidine labelling index was studied by autoradiography in 95 human macroglial tumours. In 75 supratentorial tumours the values of the labelling index ranged from 0.05% to 20.10%, while in 20 cerebellar tumours it comprised 0.05% to 1.49%. Macroglial tumours of the large hemispheres could be subdivided with statistical significance into two discrete groups according to their labelling index: the group of slowly growing tumours with the labelling index below 2.5%, and the group of faster growing tumours with the labelling index above 2.5%. Gradual spontaneous malignization of the Group 1 tumours turning into Group 2 tumours is hardly probable. The duration of the DNA synthesis phase in 4 macroglial tumours of the large hemispheres in man varied from 5.7 to 7.5 hours.
通过放射自显影术对95例人类大胶质细胞瘤的胸腺嘧啶核苷标记指数进行了研究。在75例幕上肿瘤中，标记指数值范围为0.05%至20.10%，而在20例小脑肿瘤中，其范围为0.05%至1.49%。根据标记指数，大脑半球的大胶质细胞瘤可在统计学上显著地分为两个不同的组：标记指数低于2.5%的缓慢生长肿瘤组，以及标记指数高于2.5%的快速生长肿瘤组。第1组肿瘤逐渐自发恶变为第2组肿瘤的可能性很小。人类大脑半球4例大胶质细胞瘤中DNA合成期的持续时间为5.7至7.5小时。
