非阿片类镇痛药对中枢神经系统的阿片样物质能效应。
Opioidergic effects of nonopioid analgesics on the central nervous system.
作者信息
Vanegas Horacio, Tortorici Victor
机构信息
Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
出版信息
Cell Mol Neurobiol. 2002 Dec;22(5-6):655-61. doi: 10.1023/a:1021896622089.
Abstract
- The analgesic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is partly due to the fact that they act upon the periaqueductal gray matter (PAG) and the rostral ventromedial medulla of the brain stem and thus activate the descending pain-control system, which inhibits nociceptive transmission at the spinal dorsal horn. 2. The analgesic action of dipyrone (metamizol) and of lysine-acetylsalicylate (LASA), two well-known NSAIDs. whether microinjected into the PAG or given systemically, can be reverted by naloxone. Repeated administration of dipyrone or LASA induces tolerance to their antinociceptive effect, with cross-tolerance to morphine, and a withdrawal syndrome upon naloxone administration. Dipyrone tolerance can be reverted by proglumide, a cholecystokinin antagonist. 3. These findings reveal a close association between the central action of NSAIDs and endogenous opioids.
摘要
- 非甾体抗炎药（NSAIDs）的镇痛作用部分归因于它们作用于中脑导水管周围灰质（PAG）和脑干的延髓头端腹内侧，从而激活下行性疼痛控制系统，该系统抑制脊髓背角的伤害性信息传递。2. 两种著名的NSAIDs，即安乃近（氨基比林）和赖氨匹林（LASA），无论微量注射到PAG还是全身给药，其镇痛作用均可被纳洛酮逆转。重复给予安乃近或赖氨匹林会导致对其抗伤害感受作用产生耐受性，对吗啡产生交叉耐受性，且给予纳洛酮后会出现戒断综合征。安乃近耐受性可被胆囊收缩素拮抗剂丙谷胺逆转。3. 这些发现揭示了NSAIDs的中枢作用与内源性阿片类物质之间的密切关联。
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