Paugam André, Bulteau Anne Laure, Dupouy-Camet Jean, Creuzet Claudine, Friguet Bertrand
Laboratoire Signalisation et Parasites (EA 3623), Université Paris 5, C.H.U. Cochin, 27, rue du Faubourg Saint Jacques 75014 Paris, France.
Trends Parasitol. 2003 Feb;19(2):55-9. doi: 10.1016/s1471-4922(02)00064-8.
The proteasome, a large non-lysosomal multi-subunit protease complex, is ubiquitous in eukaryotic cells. In protozoan parasites, the proteasome is involved in cell differentiation and replication, and could therefore be a promising therapeutic target. This article reviews the present knowledge of proteasomes in protozoan parasites of medical importance such as Giardia, Entamoeba, Leishmania, Trypanosoma, Plasmodium and Toxoplasma spp.
蛋白酶体是一种大型的非溶酶体多亚基蛋白酶复合物，在真核细胞中普遍存在。在原生动物寄生虫中，蛋白酶体参与细胞分化和复制，因此可能是一个有前景的治疗靶点。本文综述了在医学上具有重要意义的原生动物寄生虫（如贾第虫、溶组织内阿米巴、利什曼原虫、锥虫、疟原虫和弓形虫等）中蛋白酶体的现有知识。
Trends Parasitol. 2003-2
Trends Biochem Sci. 1994-9
Parasit Vectors. 2011-2-28
J Biochem. 1998-2
Trends Cell Biol. 1998-10
Arch Med Res. 1997
Trends Biochem Sci. 1996-3
Front Drug Discov (Lausanne). 2023-5-10
Front Cell Infect Microbiol. 2022
Int J Mol Sci. 2021-7-26
Pharmaceutics. 2021-5-19
Parasitology. 2021-9
Genes (Basel). 2020-9-2
Iran J Parasitol. 2019
Transl Res. 2018-5-3
Molecules. 2017-2-10
Cell Host Microbe. 2015-11-11
Zotero 插件