Gardner Jeff
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Clin Lab Sci. 2003 Winter;16(1):6-9.
Factor V Leiden (FVL) is an autosomal co-dominantly inherited Arg506-->Gly substitution of the activated protein C cleavage site affecting 5% of the Caucasian population. FVL results in impaired anticoagulant function without procoagulant modification. Heterozygotes experience a seven-fold increase in thrombotic events, whereas homozygotes may incur a 50 to 100 fold increase. Even though patients are at increased risk for deep venous thrombi, they experience a smaller risk of pulmonary embolism compared to individuals affected by other coagulopathies.
莱顿V因子（FVL）是一种常染色体共显性遗传的激活蛋白C裂解位点的精氨酸506突变为甘氨酸的情况，影响5%的白种人。FVL导致抗凝功能受损而无促凝修饰。杂合子发生血栓事件的风险增加7倍，而纯合子可能增加50至100倍。尽管患者发生深静脉血栓的风险增加，但与受其他凝血障碍影响的个体相比，他们发生肺栓塞的风险较小。
