Caksen Hüseyin, Tutuş Ahmet, Kurtoğlu Selim, Oztürk Figen, Okumuş Yüksel, Coksevim Bekir
Yüzüncü Yil University, Van, Faculty of Medicine, Department of Pediatrics, Turkey.
Acta Medica (Hradec Kralove). 2002;45(4):177-9.
To determine whether low dose ketoconazole (KTZ) has antithyroid action, we studied thyroid function tests in the 13 rats treated with KTZ (20 mg/kg twice daily) for thirty days. Serum triiodothyronine and thyroxine levels were decreased (P<0.05) and serum thyroid-stimulating hormone levels were mildly increased (P>0.05) at the end of treatment. Histopathological analysis of the thyroid glands demonstrated an increase in cylindrical cells in study group, but the epithelial cells were mainly cubical in control group. These findings showed that low dose KTZ had antithyroid effect in rats. The responsible mechanisms may be direct effect of the drug on thyroid gland.
为确定低剂量酮康唑（KTZ）是否具有抗甲状腺作用，我们对13只大鼠进行了研究，这些大鼠每日两次接受KTZ（20毫克/千克）治疗，持续30天，并检测其甲状腺功能。治疗结束时，血清三碘甲状腺原氨酸和甲状腺素水平降低（P<0.05），血清促甲状腺激素水平略有升高（P>0.05）。甲状腺组织病理学分析显示，研究组柱状细胞增多，而对照组上皮细胞主要为立方形。这些结果表明，低剂量KTZ对大鼠具有抗甲状腺作用。其作用机制可能是药物对甲状腺的直接作用。
