Saliba M J, Covell J W, Bloor C M
Am J Cardiol. 1976 Mar 31;37(4):599-604. doi: 10.1016/0002-9149(76)90401-x.
Heparin in large doses significantly improved epicardial electrocardiographic findings and preserved myocardial tissue and creatine phosphokinase (CPK) after coronary ligation in the dog. Epicardial S-T segment elevation 15 minutes after occlusion was lowered 84% (from 64.5 + 8.5 [standard error of the mean] to 10.4 +/- 3.0 mv) by heparin infusions of 60,000 units. Myocardial creatine phosphokinase depletion was reduced from 39 to 24% at comparable levels of S-T segment elevation. Histologic evidence of necrosis decreased 32%. It is concluded that heparin can reduce the extent of ischemic injury after acute coronary occlusion in the dog. These results may lend insight into the factors responsible for ischemic injury.
大剂量肝素能显著改善犬冠状动脉结扎后的心外膜心电图表现，并保护心肌组织和肌酸磷酸激酶（CPK）。闭塞后15分钟的心外膜S-T段抬高，通过输注60,000单位肝素降低了84%（从64.5 + 8.5[均值标准误差]降至10.4 +/- 3.0毫伏）。在相当的S-T段抬高水平下，心肌肌酸磷酸激酶的消耗从39%降至24%。坏死的组织学证据减少了32%。得出的结论是，肝素可减轻犬急性冠状动脉闭塞后的缺血性损伤程度。这些结果可能有助于深入了解缺血性损伤的相关因素。
