Lee Wen-Ying
Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.
Cytopathology. 2003 Feb;14(1):19-26. doi: 10.1046/j.1365-2303.2003.00419.x.
Spontaneous or expressible nipple discharge may occur in palpable and nonpalpable breast lesions. The aim of the study was to evaluate the sensitivity and specificity of nipple discharge cytology in palpable and nonpalpable breast lesions. One hundred and seventy-four nipple discharge specimens were reviewed, of which 82 had corresponding surgical pathology, including 34 palpable breast lesions and 48 nonpalpable breast lesions. There was good correlation between nipple discharge cytology and concomitant fine needle aspiration (FNA) cytology. Nipple discharge cytology is as specific as concomitant FNA cytology but is slightly less sensitive in detecting papillomas or malignant lesions. The sensitivity and specificity of the nonpalpable and palpable breast lesions were similar. Nipple discharge cytology is very helpful in detecting an underlying breast lesion even if the case has no palpable mass in the breast.
自发性或可挤出性乳头溢液可能出现在可触及和不可触及的乳腺病变中。本研究的目的是评估乳头溢液细胞学检查在可触及和不可触及乳腺病变中的敏感性和特异性。回顾了174份乳头溢液标本，其中82份有相应的手术病理结果，包括34例可触及的乳腺病变和48例不可触及的乳腺病变。乳头溢液细胞学检查与同期细针穿刺（FNA）细胞学检查之间存在良好的相关性。乳头溢液细胞学检查与同期FNA细胞学检查一样具有特异性，但在检测乳头状瘤或恶性病变方面敏感性略低。不可触及和可触及乳腺病变的敏感性和特异性相似。即使病例乳腺中未触及肿块，乳头溢液细胞学检查在检测潜在乳腺病变方面也非常有帮助。
