Reif A, Schneider M F, Hoyer A, Schneider-Gold C, Fallgatter A J, Roggendorf W, Pfuhlmann B
Department of Psychiatry and Psychotherapy, Julius-Maximilians-University Würzburg, Germany.
J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):385-7. doi: 10.1136/jnnp.74.3.385.
A patient with adult neuronal ceroid lipofuscinosis (ANCL; Kufs' disease) is described in whom neuroleptic malignant syndrome occurred, initially presenting as catatonic syndrome. Comprehensive neuroimaging studies were conducted including FDG-PET, IBZM-SPECT, and beta-CIT-SPECT, electrophysiological examinations and an ex vivo contracture test exposing muscle biopsy specimens to neuroleptics. Collectively the results argued for an involvement of the muscle in neuroleptic malignant syndrome at least in ANCL.
本文描述了一名患有成人神经元蜡样脂褐质沉积症（ANCL；库夫斯病）的患者，该患者发生了抗精神病药恶性综合征，最初表现为紧张症综合征。进行了全面的神经影像学研究，包括氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）、碘苄酰胺单光子发射计算机断层扫描（IBZM-SPECT）和β-羧基哌嗪三氟甲基苯并噻唑啉酮单光子发射计算机断层扫描（β-CIT-SPECT）、电生理检查以及将肌肉活检标本暴露于抗精神病药的离体挛缩试验。总体结果表明，至少在ANCL中，肌肉参与了抗精神病药恶性综合征。
