Luengo-Márquez C, Gallego-Moreno J, Laguía-Almansa L, Martín-Sebastia E, Abizanda-Soler P, Romero-Rizos L
Sección de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.
Rev Neurol. 2003;36(2):118-21.
Different neurological disorders affecting different levels of the nervous system, both central and peripheral, are included among the paraneoplastic symptomologies of cancers, although their incidence is not well defined and varies according to the type of tumour.
We report the case of a 73 year old male patient who was admitted with a suspected polyneuropathy that had been developing for one month. The diagnosis was confirmed by electromyography. The only probable aetiology found in the course of a specific exploration was an adenocarcinoma of the prostate, with a widespread distribution throughout the central ganglionic chains and bone metastases, which were observed by computerised tomography of the abdomino pelvic region and bone gammography, and had not previously been diagnosed.
We reviewed the literature on the relation between neurological paraneoplastic syndromes and neoplasias that are not of a pulmonary origin and we found a low rate of association between the two processes. The relation between adenocarcinoma of the prostate and neurological paraneoplastic processes receives very little attention. These syndromes vary greatly in their neurological expression, and there is a link with different antibodies that could explain an etiopathogenic mechanism of an immunitary nature. No effective treatment exists in spite of its usually being aggressive and varied. The disease often progresses quickly and leads to death after a few months.
尽管癌症副肿瘤症状的发病率尚无明确定义且因肿瘤类型而异，但影响中枢和外周神经系统不同水平的各种神经系统疾病都包含在其中。
我们报告一例73岁男性患者，因疑似多发性神经病入院，该病已发展一个月。肌电图检查确诊了该诊断。在特定检查过程中发现的唯一可能病因是前列腺腺癌，通过腹部盆腔计算机断层扫描和骨闪烁造影观察到其在中枢神经节链广泛分布并伴有骨转移，此前未被诊断出。
我们回顾了关于非肺源性肿瘤与神经副肿瘤综合征之间关系的文献，发现这两个过程之间的关联率较低。前列腺腺癌与神经副肿瘤过程之间的关系很少受到关注。这些综合征在神经表现上差异很大，并且与不同抗体有关联，这可能解释了一种免疫性质的病因机制。尽管通常具有侵袭性且多样，但目前尚无有效的治疗方法。该疾病通常进展迅速，数月后导致死亡。
