手术绝经后血流介导的血管舒张的快速变化。
Rapid changes of flow-mediated dilatation after surgical menopause.
作者信息
Ohmichi Masahide, Kanda Yuki, Hisamoto Koji, Morishige Ken-ichiro, Takahashi Kazuhiro, Sawada Kenjiro, Minekawa Ryoko, Tasaka Keiichi, Murata Yuji
机构信息
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
出版信息
Maturitas. 2003 Feb 25;44(2):125-31. doi: 10.1016/s0378-5122(02)00320-1.
OBJECTIVES
Estrogen acts directly on endothelial nitric oxide synthase through a non-genomic mechanism, resulting in rapid dilatation of blood vessels. In this study, we examined the change of endothelial function after surgical menopause.
METHODS
In 20 subjects who underwent gynecological operations (ovariectomy (OVX) 12, sham (SHAM) operation 8), postoperative changes of flow-mediated dilatation (FMD) of the brachial artery were examined using ultrasonography. Postoperative changes of the response to nitroglycerin (NTG) were also studied in these patients.
RESULTS
In the OVX group, significant decreases of FMD were observed 1 week after the operation, although no changes were observed in the response to NTG. In the SHAM group, no remarkable changes of FMD or the response to NTG were observed after the operation.
CONCLUSIONS
OVX influences endothelium-dependent vasodilatation within as little as 1 week. Therefore, it may be important to address the rapid changes of circulation after surgical menopause in order to prevent cardiovascular disease.
目的
雌激素通过非基因组机制直接作用于内皮型一氧化氮合酶，导致血管迅速扩张。在本研究中，我们检测了手术绝经后内皮功能的变化。
方法
对20例接受妇科手术的患者（12例行卵巢切除术（OVX），8例行假手术（SHAM）），采用超声检查术后肱动脉血流介导的血管舒张（FMD）变化。同时研究这些患者术后对硝酸甘油（NTG）反应的变化。
结果
在OVX组，术后1周观察到FMD显著降低，而对NTG的反应未见变化。在SHAM组，术后FMD或对NTG的反应未见明显变化。
结论
卵巢切除术在短短1周内即可影响内皮依赖性血管舒张。因此，为预防心血管疾病，应对手术绝经后循环系统的快速变化予以关注，这可能很重要。
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