Departments of Orthopaedic Surgery/Cardiovascular Center.
J Sports Sci Med. 2009 Mar 1;8(1):123-9. eCollection 2009.
The purpose of this study was to determine if six weeks of folic acid supplementation would improve brachial artery endothelial-dependent flow-mediated dilation in eumenorrheic female runners with previously normal serum folate levels. This was a prospective, double-blinded, randomized pilot study with convenience sampling. Sixteen eumenorrheic subjects who were not taking birth control pills and who ran at least 20 miles/week were randomly assigned to 10 mg/day of folic acid supplementation or placebo for at least 6 weeks. Serum folate levels and brachial artery measurements were made during the early follicular phase of the menstrual cycle, in a sedentary state, following an 8 hour fast; a standard ultrasound technique was used. The brachial artery vasodilator response to reactive hyperemia was similar between the folic acid (6.6% ± 0.8%, mean ± SE) and placebo groups (6.5% ± 0.7%) at baseline. After six weeks, there was a significantly higher change in flow-mediated dilation for the folic acid group (3.5% ± 0.6%) compared to the placebo group (0.1% ± 0.2%) (p = 0.01). Serum folate levels also increased significantly in the folic acid group following six weeks of folic acid supplementation. This study demonstrates that brachial artery flow-mediated dilation improves significantly in eumenorrheic female runners with previously normal serum folate levels after 6 weeks of supplementation with folic acid. Key pointsFolic acid improves FMD in eumenorrheic runners.Folic acid improves FMD in women runners.
这项研究的目的是确定补充叶酸 6 周是否可以改善月经正常的女性跑步者的肱动脉内皮依赖性血流介导的扩张。这是一项前瞻性、双盲、随机的初步研究，采用便利抽样。16 名月经正常、未服用避孕药且每周至少跑步 20 英里的女性被随机分配每天服用 10 毫克叶酸或安慰剂至少 6 周。在月经周期的卵泡早期、空腹 8 小时、处于安静状态下，测量血清叶酸水平和肱动脉测量值；使用标准超声技术。在基线时，叶酸组（6.6%±0.8%，平均值±SE）和安慰剂组（6.5%±0.7%）的肱动脉血管扩张反应对反应性充血相似。6 周后，叶酸组的血流介导扩张变化明显更高（3.5%±0.6%），而安慰剂组（0.1%±0.2%）（p=0.01）。补充叶酸 6 周后，叶酸组的血清叶酸水平也显著升高。这项研究表明，在补充叶酸 6 周后，血清叶酸水平正常的月经正常女性跑步者的肱动脉血流介导扩张明显改善。关键点叶酸可改善月经正常跑步者的 FMD。叶酸可改善女性跑步者的 FMD。
