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绝育治疗前的女性生育力保存:卵巢组织冷冻保存的作用

[Female fertility preservation before sterilizing treatment: contribution of ovarian tissue cryopreservation].

作者信息

Poirot C, Martelli H, Lichtblau I, Dhedin N, Abirached F, Faraguet C, Vacher-Lavenu M-C

机构信息

Unité Fonctionnelle de Biologie de la Reproduction, Groupe Hospitalier Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2002 Dec;31(8):717-23.

Abstract

Longer survival after anticancer treatment has lead to concern about the long-term adverse effects. Altered fertility is of particular importance. Before sterilizing treatment, three non-exclusive methods can be proposed to preserve female fertility: in vitro fertilization followed by cryopreservation of embryos, cryopreservation of mature ovocytes, cryopreservation of ovarian tissue. The method or methods chosen will depend on the age of the patient, here marital status, the urgency of the treatment, and the type of disease. Embryo cryopreservation is a routine practice in medically assisted reproduction centers, while cryopreservation of mature ovocytes and ovarian tissue is still in the experimental phase. It is known however that mature ovocytes can be used after cryopreservation. Cyropreservation of ovarian tissue is a more difficult problem. To date, there have not been any pregnancies or births after freezing-thawing of human ovarian tissue. This tissue could be used in two ways: autograft and in vitro folliculo-ovocyte maturation. Despite the uncertainty concerning use, women cryopreservation of ovarian tissue quite well.

摘要

抗癌治疗后生存期延长引发了人们对长期不良反应的关注。生育能力改变尤为重要。在进行绝育治疗前,可提出三种非排他性方法来保存女性生育能力:体外受精后冷冻保存胚胎、冷冻保存成熟卵母细胞、冷冻保存卵巢组织。所选择的方法将取决于患者年龄、婚姻状况、治疗紧迫性以及疾病类型。胚胎冷冻保存是医学辅助生殖中心的常规操作,而成熟卵母细胞和卵巢组织的冷冻保存仍处于实验阶段。然而,已知成熟卵母细胞冷冻保存后仍可使用。卵巢组织冷冻保存是一个更棘手的问题。迄今为止,人类卵巢组织冻融后尚未有任何妊娠或分娩案例。该组织可通过两种方式使用:自体移植和体外卵泡-卵母细胞成熟。尽管使用存在不确定性,但女性卵巢组织冷冻保存效果良好。

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