Tolman K G, Hammar S, Sannella J J
Ann Intern Med. 1976 Mar;84(3):290-2. doi: 10.7326/0003-4819-84-3-290.
A patient with chronic constipation developed liver injury and leukopenia following the ingestion of Doxidan, a combination drug consisting of danthron and dioctyl calcium sulfosuccinate. Evidence is presented that dioctyl calcium sulfosuccinate may have potentiated the toxicity. The liver injury was associated with deposition of IgE in the Kupffer cells. The mechanism of toxicity remains unclear.
一名慢性便秘患者在服用多库酯钠（一种由丹蒽醌和磺琥辛酯钙组成的复方药物）后出现肝损伤和白细胞减少。有证据表明，磺琥辛酯钙可能增强了毒性。肝损伤与库普弗细胞中IgE的沉积有关。毒性机制尚不清楚。
