[1,1,1-三氯乙烷所致慢性活动性肝炎]

[1,1, 1-trichloroethane-induced chronic active hepatitis].

作者信息

Croquet Vincent, Fort Joël, Oberti Frédéric, Roquelaure Yves, Ben Bouali Abdel Kader, Pilette Christophe, Calès Paul

机构信息

Service d'Hépato-Gastroentérologie, CHU, 49033 Angers Cedex 01.

出版信息

Gastroenterol Clin Biol. 2003 Jan;27(1):120-2.

PMID:12594376

Abstract

1,1, 1-trichloroéthane is derived from carbon tetrachloride and has been widely used as an industrial solvent since 1954, because of its supposed lack of toxicity. However, several cases of central nervous system toxicity and heart disorders due to intoxication by 1,1, 1-trichloroéthane have been reported. Cases of liver injury are infrequent, with less than 10 cases, unlike 1,1, 2-trichloroéthane that it replaced. We report a case of hepatotoxicity probably due to 1,1, 1-trichloroéthane exposure, characterized by an original pathologic feature of chronic active hepatitis.

摘要

1,1,1-三氯乙烷由四氯化碳衍生而来，自1954年以来因其假定的低毒性而被广泛用作工业溶剂。然而，已有多例因1,1,1-三氯乙烷中毒导致中枢神经系统毒性和心脏疾病的报告。肝损伤病例并不常见，少于10例，这与它所取代的1,1,2-三氯乙烷不同。我们报告一例可能因接触1,1,1-三氯乙烷导致的肝毒性病例，其特征为慢性活动性肝炎的一种独特病理表现。