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结直肠手术患者中POSSUM和P-POSSUM评分系统的评估

Evaluation of POSSUM and P-POSSUM scoring systems in patients undergoing colorectal surgery.

作者信息

Tekkis P P, Kessaris N, Kocher H M, Poloniecki J D, Lyttle J, Windsor A C J

机构信息

Academic Department of Surgery, King's College Hospital, London, UK.

出版信息

Br J Surg. 2003 Mar;90(3):340-5. doi: 10.1002/bjs.4037.

Abstract

BACKGROUND

The Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) and Portsmouth POSSUM (P-POSSUM) equations were derived from a heterogeneous general surgical population and have been used successfully as audit tools to provide risk-adjusted operative mortality rates. Their applicability to high-risk emergency colorectal operations has not been established.

METHODS

POSSUM variables were recorded for 1017 patients undergoing major elective (n = 804) or emergency (n = 213) colorectal surgery in ten hospitals. Subgroup analysis was performed to investigate the predictive capability of POSSUM and P-POSSUM in emergency and elective surgery and in patients in different age groups.

RESULTS

The overall operative mortality rate was 7.5 per cent (POSSUM-estimated mortality rate 8.2 per cent; P-POSSUM-estimated mortality rate 7.1 per cent). In-hospital deaths increased exponentially with age. Both scoring systems overpredicted mortality in young patients and underpredicted mortality in the elderly (P < 0.001). Death was underpredicted by both systems for emergency cases, significantly so at a simulated emergency caseload of 47.9 per cent (P < 0.05).

CONCLUSION

There is a lack of calibration of POSSUM and P-POSSUM systems at the extremes of age and high emergency workload. This has important implication in clinical practice, as consultants with a high emergency workload may seem to underperform when these scoring systems are applied. Recalibration or remodelling strategies may facilitate the application of POSSUM-based systems in colorectal surgery.

摘要

背景

用于计算死亡率和发病率的生理与手术严重程度评分(POSSUM)及朴茨茅斯POSSUM(P-POSSUM)方程源自一个异质性的普通外科人群,并已成功用作审计工具以提供风险调整后的手术死亡率。它们在高风险急诊结直肠手术中的适用性尚未确立。

方法

记录了十家医院中1017例行择期(n = 804)或急诊(n = 213)大结直肠手术患者的POSSUM变量。进行亚组分析以研究POSSUM和P-POSSUM在急诊和择期手术以及不同年龄组患者中的预测能力。

结果

总体手术死亡率为7.5%(POSSUM估计死亡率为8.2%;P-POSSUM估计死亡率为7.1%)。院内死亡随年龄呈指数增加。两个评分系统均高估了年轻患者的死亡率,低估了老年患者的死亡率(P < 0.001)。对于急诊病例,两个系统均低估了死亡率,在模拟急诊病例负荷为47.9%时差异显著(P < 0.05)。

结论

POSSUM和P-POSSUM系统在年龄极端情况和高急诊工作量时缺乏校准。这在临床实践中有重要意义,因为当应用这些评分系统时,急诊工作量大的顾问医生可能看起来表现不佳。重新校准或重塑策略可能有助于基于POSSUM的系统在结直肠手术中的应用。

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