Constantinides Vasilis A, Tekkis Paris P, Senapati Asha
Department of Surgical Oncology and Technology, Imperial College London, St. Mary's Hospital, Praed Street, London W2 1NY, U.K.
Dis Colon Rectum. 2006 Sep;49(9):1322-31. doi: 10.1007/s10350-006-0522-5.
This study was designed to evaluate the accuracy of the Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity, Portsmouth-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity, colorectal-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity, and the Surgical Risk Scale for the treatment of patients with complicated diverticular disease.
Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity variables were prospectively recorded for 324 patients undergoing colorectal resections in 42 hospitals in the United Kingdom from January to December 2003. The accuracy of each model was evaluated by measures of discrimination, calibration, and subgroup analysis.
The overall operative mortality was 10.8 percent (Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity-estimated mortality rate, 21.9 percent; Portsmouth-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity-estimated mortality rate, 10.5 percent; colorectal-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity-estimated mortality rate, 10 percent; Surgical Risk Scale-estimated mortality rate, 38.2 percent). Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity and the Surgical Risk Scale over-predicted mortality in young patients (P < 0.001) and Portsmouth-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity underpredicted mortality in elderly patients (P < 0.001). Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity and the Surgical Risk Scale overpredicted mortality in patients with generalized peritonitis (Hinchey III and IV). There was no significant difference between the observed and colorectal-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity predicted mortality across patient subgroups and when the overall sample was considered.
The study suggested a lack of calibration of Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity, Portsmouth-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity, and the Surgical Risk Scale at the extreme of age and for patients with severe peritoneal contamination. Colorectal-Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity was found to accurately evaluate mortality arising from complicated diverticular disease.
本研究旨在评估用于计算死亡率和发病率的生理与手术严重程度评分(P-POSSUM)、朴茨茅斯生理与手术严重程度评分(P-POSSUM)、结直肠生理与手术严重程度评分(CR-POSSUM)以及治疗复杂性憩室病患者的手术风险量表的准确性。
前瞻性记录了2003年1月至12月在英国42家医院接受结直肠切除术的324例患者的用于计算死亡率和发病率的生理与手术严重程度评分变量。通过区分度、校准度和亚组分析来评估每个模型的准确性。
总体手术死亡率为10.8%(用于计算死亡率和发病率的生理与手术严重程度评分估计死亡率为21.9%;朴茨茅斯生理与手术严重程度评分估计死亡率为10.5%;结直肠生理与手术严重程度评分估计死亡率为10%;手术风险量表估计死亡率为38.2%)。用于计算死亡率和发病率的生理与手术严重程度评分以及手术风险量表高估了年轻患者的死亡率(P<0.001),而朴茨茅斯生理与手术严重程度评分低估了老年患者的死亡率(P<0.001)。用于计算死亡率和发病率的生理与手术严重程度评分以及手术风险量表高估了弥漫性腹膜炎(欣奇伊III级和IV级)患者的死亡率。在各患者亚组以及考虑总体样本时,观察到的死亡率与结直肠生理与手术严重程度评分预测的死亡率之间无显著差异。
该研究表明,用于计算死亡率和发病率的生理与手术严重程度评分、朴茨茅斯生理与手术严重程度评分以及手术风险量表在年龄极端情况和严重腹膜污染患者中缺乏校准度。发现结直肠生理与手术严重程度评分能准确评估复杂性憩室病引起的死亡率。