在母亲与胎儿之间的先天边界处：将流产与补体激活联系起来。

At the innate frontiers between mother and fetus: linking abortion with complement activation.

作者信息

Caucheteux Stéphane M, Kanellopoulos-Langevin Colette, Ojcius David M

机构信息

Jacques Monod Institute, Laboratory of Immune Regulations and Development, UMR7592, CNRS, Paris cedex, France.

出版信息

Immunity. 2003 Feb;18(2):169-72. doi: 10.1016/s1074-7613(03)00028-1.

DOI:10.1016/s1074-7613(03)00028-1

PMID:12594944

Abstract

The intricate mechanisms regulating fetomaternal interactions are still largely uncharacterized. Recent papers have revealed a major role for the innate immune system during abortion. Different experimental conditions-deletion of a complement regulator, injection of anti-phospholipid antibodies into mothers, or allo-recognition of fetuses in the presence of an IDO inhibitor-all lead to complement activation, inflammation, and fetal loss. These observations also raise new questions on the relationship between the adaptive and innate systems during pregnancy.

摘要

调节母胎相互作用的复杂机制在很大程度上仍未得到充分表征。最近的论文揭示了先天性免疫系统在流产过程中的主要作用。不同的实验条件——补体调节因子的缺失、向母体注射抗磷脂抗体，或在吲哚胺2,3-双加氧酶抑制剂存在的情况下对胎儿进行同种异体识别——都会导致补体激活、炎症和胎儿丢失。这些观察结果也引发了关于孕期适应性免疫系统与先天性免疫系统之间关系的新问题。