Dallenbach-Hellweg G, Grumbrecht C
Virchows Arch A Pathol Anat Histol. 1975 Aug 12;367(3):241-54. doi: 10.1007/BF00430711.
This study was undertaken to determine whether the hormonal sensitivity of the endometrium might be a measure of the effectiveness of hormonal therapy for adenomyosis and endometriosis. Accordingly, the effects of endogenous and exogenous hormones on the endometrium, adenomyosis, and endometriosis were correlated. The results revealed that, depending on where the ectopic endometrial tissue was located and on the type (duration and intensity) of hormonal treatment, the functional response of the endometriosis varied from that of the endometrium. The variations, however, can be predicted. The response of adenomyosis to hormonal stimulation was most like that of the endometrium. Endometriosis of the ovary often revealed an excessive response to stimulation, especially after gestagens. The other types of extrauterine foci of endometriosis, however, reacted only weakly to hormonal therapy. Important prognostic consequence for therapy can be drawn from the results.
本研究旨在确定子宫内膜的激素敏感性是否可作为衡量子宫腺肌病和子宫内膜异位症激素治疗效果的指标。因此，对内源性和外源性激素对子宫内膜、子宫腺肌病和子宫内膜异位症的影响进行了相关性分析。结果显示，根据异位子宫内膜组织的位置以及激素治疗的类型（持续时间和强度），子宫内膜异位症的功能反应与子宫内膜的反应有所不同。然而，这些差异是可以预测的。子宫腺肌病对激素刺激的反应最类似于子宫内膜。卵巢子宫内膜异位症通常对刺激表现出过度反应，尤其是在使用孕激素之后。然而，其他类型的子宫外子宫内膜异位症病灶对激素治疗的反应较弱。这些结果可为治疗提供重要的预后依据。
