细菌[铜，锌]辅助因子超氧化物歧化酶可保护调理后的、有荚膜的脑膜炎奈瑟菌不被人类单核细胞/巨噬细胞吞噬。
Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages.
作者信息
Dunn Kate L R, Farrant Jayne L, Langford Paul R, Kroll J Simon
机构信息
Molecular Infectious Diseases Group, Department of Paediatrics, Faculty of Medicine, Imperial College, St. Mary's Hospital Campus, London W2 1PG, United Kingdom.
出版信息
Infect Immun. 2003 Mar;71(3):1604-7. doi: 10.1128/IAI.71.3.1604-1607.2003.
Abstract
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.
摘要
由铜和锌作为辅因子的超氧化物歧化酶（[Cu,Zn]-SOD）有助于保护调理后的B群脑膜炎奈瑟菌免受人类单核细胞/巨噬细胞的吞噬作用，sodC突变体被内吞的数量明显高于野生型生物体。研究发现，[Cu,Zn]-SOD的影响作用于吞噬阶段，而非更早（调节表面结合）或更晚（细胞内杀伤）阶段。
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