Luby Joan L, Heffelfinger Amy K, Mrakotsky Christine, Brown Kathy M, Hessler Martha J, Wallis Jeffrey M, Spitznagel Edward L
Washington University School of Medicine, Department of Psychiatry, St. Louis, MO 63110, USA.
J Am Acad Child Adolesc Psychiatry. 2003 Mar;42(3):340-8. doi: 10.1097/00004583-200303000-00015.
To investigate the clinical characteristics of depression in preschool children.
One hundred seventy-four subjects between the ages of 3.0 and 5.6 years were ascertained from community and clinical sites for a comprehensive assessment that included an age-appropriate psychiatric interview for parents. Modifications were made to the assessment of major depressive disorder (MDD) criteria so that age-appropriate manifestations of symptom states could be captured. Typical and "masked" symptoms of depression were investigated in three groups: depressed (who met all MDD criteria except duration criterion), those with nonaffective psychiatric disorders (who met criteria for attention-deficit/hyperactivity disorder and/or oppositional defiant disorder), and those who did not meet criteria for any psychiatric disorder.
Depressed preschool children displayed "typical" symptoms and vegetative signs of depression more frequently than other nonaffective or "masked" symptoms. Anhedonia appeared to be a specific symptom and sadness/irritability appeared to be a sensitive symptom of preschool MDD.
Clinicians should be alert to age-appropriate manifestations of typical MDD symptoms and vegetative signs when assessing preschool children for depression. "Masked" symptoms of depression occur in preschool children but do not predominate the clinical picture. Future studies specifically designed to investigate the specificity and sensitivity of the symptoms of preschool depression are now warranted.
探讨学龄前儿童抑郁症的临床特征。
从社区和临床机构确定了174名年龄在3.0至5.6岁之间的受试者,进行全面评估,包括对家长进行适合其年龄的精神科访谈。对重度抑郁症(MDD)标准的评估进行了修改,以便能够捕捉到适合其年龄的症状表现。在三组中调查了抑郁症的典型症状和“隐匿”症状:抑郁组(符合除病程标准外的所有MDD标准)、患有非情感性精神障碍组(符合注意力缺陷多动障碍和/或对立违抗障碍标准)以及未符合任何精神障碍标准组。
与其他非情感性或“隐匿”症状相比,抑郁的学龄前儿童更频繁地表现出抑郁症的“典型”症状和躯体症状。快感缺失似乎是学龄前MDD的一种特异性症状,悲伤/易激惹似乎是一种敏感症状。
临床医生在评估学龄前儿童是否患有抑郁症时,应警惕典型MDD症状和躯体症状的适合其年龄的表现。抑郁症的“隐匿”症状在学龄前儿童中存在,但并非临床症状的主要表现。现在有必要开展专门研究学龄前抑郁症症状特异性和敏感性的未来研究。