Rawashdeh Yazan F, Hørlyck Arne, Mortensen Jens, Hvistendahl Jan J, Frokiaer Jorgen, Djurhuus Jens C
Institute of Experimental Clinical Research, Aarhus University, Aarhus, Denamark.
Invest Radiol. 2003 Mar;38(3):153-8. doi: 10.1097/01.RLI.0000053669.70347.33.
To study the effects of acute complete unilateral ureteral obstruction (UUO) and release on porcine renal resistive index (RI).
Under general anesthesia, UUO was induced in six pigs. RI was measured bilaterally at predetermined intervals for 4 hours of UUO and 1 hour of release. Additionally, measures of renal blood flow (RBF), glomerular filtration rate (GFR), arterial blood pressure, renal vascular resistance (RVR), and ipsilateral renal intrapelvic pressure (IPP) were obtained.
UUO and resultant progressive IPP increase caused prompt and significant ipsilateral RI elevation, and contralateral RI decrease. Concomitantly, ipsilateral RVR increased significantly while RBF and GFR declined, both significantly. Release of obstruction saw an almost immediate normalization of ipsilateral RI, RVR and RBF while ipsilateral GFR assumed 80% of baseline value 15 minutes postobstruction. Throughout the experiment, ipsilateral RI correlated significantly with changes in IPP, GFR, RBF, and RVR with correlation coefficients of 0.844, -0.851, -0.898, and 0.836 respectively ( < 0.001).
UUO causes a divergent RI response that is instantly reversed upon release. IPP seems to be the principal effector of these changes in the early phases of UUO.
研究急性完全性单侧输尿管梗阻（UUO）及其解除对猪肾阻力指数（RI）的影响。
在全身麻醉下，对6头猪诱导产生UUO。在UUO的4小时及解除梗阻1小时期间，按预定时间间隔双侧测量RI。此外，还获取了肾血流量（RBF）、肾小球滤过率（GFR）、动脉血压、肾血管阻力（RVR）和同侧肾盂内压（IPP）的测量值。
UUO及随之而来的IPP逐渐升高导致同侧RI迅速且显著升高，对侧RI降低。同时，同侧RVR显著增加，而RBF和GFR均显著下降。解除梗阻后，同侧RI、RVR和RBF几乎立即恢复正常，而同侧GFR在梗阻后15分钟达到基线值的80%。在整个实验过程中，同侧RI与IPP、GFR、RBF和RVR的变化显著相关，相关系数分别为0.844、 - 0.851、 - 0.898和0.836（<0.001）。
UUO引起不同的RI反应，解除梗阻后立即逆转。IPP似乎是UUO早期这些变化的主要影响因素。
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