一种枝顶孢属真菌菌株将霉菌毒素玉米赤霉烯酮生物转化为一种非雌激素化合物

Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

作者信息

Kakeya Hideaki, Takahashi-Ando Naoko, Kimura Makoto, Onose Rie, Yamaguchi Isamu, Osada Hiroyuki

机构信息

Antibiotics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

出版信息

Biosci Biotechnol Biochem. 2002 Dec;66(12):2723-6. doi: 10.1271/bbb.66.2723.

DOI:10.1271/bbb.66.2723

PMID:12596876

Abstract

Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell proliferation assay.

摘要

玉米赤霉烯酮是一类具有雌激素活性的霉菌毒素，由一个间苯二酚部分与一个14元大环内酯稠合而成，由多种镰刀菌属物种产生。我们发现粉红粘帚霉IFO 7063能够有效地将玉米赤霉烯酮（1）转化为裂解产物（2），即1-(3,5-二羟基苯基)-10'-羟基-1'E-十一碳烯-6'-酮。此外，在人乳腺癌MCF-7细胞增殖试验中，裂解产物2不像1和17β-雌二醇那样具有强大的雌激素活性。