Guide Shireen V, Stock Frida, Gill Vee J, Anderson Victoria L, Malech Harry L, Gallin John I, Holland Steven M
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases and Clinical Research Training Program/NIH, 10 Center Drive, Bethesda, MD 20892, USA.
J Infect Dis. 2003 Mar 1;187(5):845-53. doi: 10.1086/368388. Epub 2003 Feb 24.
Chronic granulomatous disease (CGD) is characterized by severe recurrent infections with Staphylococcus aureus, certain gram-negative rods, Nocardia species, and fungi. When infections with the same species recur, they may represent relapses or new infections. We collected organisms from infections that occurred between 1992 and 2000 in patients with CGD and determined the biochemical phenotypes, in vitro antibiotic susceptibility patterns, and pulsed-field gel electrophoresis (PFGE) patterns of the organisms causing the initial and recurrent infections. Recurrence of infection with Burkholderia cepacia or Serratia marcescens was caused by a new strain in 9 of 10 cases (P=.001). Recurrent S. aureus infections were caused by new strains in 7 of 8 cases (P=.006). In patients with CGD, recurrence of infection with the same bacterial species after appropriate antibiotic therapy usually represents new infection.
慢性肉芽肿病（CGD）的特征是严重反复感染金黄色葡萄球菌、某些革兰氏阴性杆菌、诺卡氏菌属和真菌。当同一菌种的感染复发时，它们可能代表复发或新感染。我们收集了1992年至2000年间CGD患者感染的病原体，并确定了导致初始感染和复发感染的病原体的生化表型、体外抗生素敏感性模式和脉冲场凝胶电泳（PFGE）模式。洋葱伯克霍尔德菌或粘质沙雷氏菌感染的复发在10例中有9例是由新菌株引起的（P = 0.001）。金黄色葡萄球菌复发感染在8例中有7例是由新菌株引起的（P = 0.006）。在CGD患者中，经过适当抗生素治疗后同一细菌菌种的感染复发通常代表新感染。
