TGFbeta-induced factor: a candidate gene for high myopia.
作者信息
Lam Dennis Shun Chiu, Lee Wing Shan, Leung Yuk Fai, Tam Pancy Oi Sin, Fan Dorothy S P, Fan Bao Jian, Pang Chi Pui
机构信息
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong.
出版信息
Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1012-5. doi: 10.1167/iovs.02-0058.
PURPOSE
To investigate the coding exons of transforming growth factor (TGF)-beta-induced factor (TGIF) for mutations in Chinese patients with high myopia.
METHODS
Seventy-one individuals with high myopia of -6.00 D or less and 105 control subjects were screened by DNA sequencing for sequence alterations. Univariate analysis and logistic regression were performed to identify single-nucleotide polymorphisms (SNPs) and their interactions in TGIF that may be associated with myopia.
RESULTS
Six SNPs showed a significant difference (P < 0.05) between patient and control subject in univariate analysis. Four of them cause codon changes: G223R, G231S, P241T, and A262G. Among all the SNPs that entered multivariate analysis, only 657(T-->G) showed statistical significance in the logistic regression model (odds ratio 0.133; 95% confidence interval 0.037-0.488; P = 0.002).
CONCLUSIONS
TGIF is a probable candidate gene for high myopia. Further studies are needed to identify the underlying mechanism.
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