非苯乙胺类食欲抑制剂马吲哚对生物胺水平及周转率的影响。
Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate.
作者信息
Carruba M O, Groppetti A, Mantegazza P, Vicentini L, Zambotti F
出版信息
Br J Pharmacol. 1976 Apr;56(4):431-6. doi: 10.1111/j.1476-5381.1976.tb07454.x.
Abstract
1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.
摘要
- 马吲哚是一种新型食欲抑制剂，其化学结构与苯乙胺类不同，但药理学特征与（+）-苯丙胺相似。2. 马吲哚既不改变全脑单胺水平（去甲肾上腺素（NA）、多巴胺、5-羟色胺（5-HT）），也不改变下丘脑的NA水平或尾状核中的多巴胺水平。3. 马吲哚提高了尾状核中的多巴胺周转率，如通过α-甲基对酪氨酸阻断儿茶酚胺合成后多巴胺下降速率增加所示，并降低了（3H）-酪氨酸向脑NA的转化指数。4. 给予马吲哚并未改变帕吉林诱导的5-羟吲哚乙酸下降，表明该药物不会改变5-HT周转率。
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