接受高剂量吸入性糖皮质激素治疗哮喘的儿童出现肾上腺危象。
Adrenal crises in children treated with high-dose inhaled corticosteroids for asthma.
作者信息
Macdessi Joseph S, Randell Tabitha L, Donaghue Kim C, Ambler Geoffrey R, van Asperen Peter P, Mellis Craig M
机构信息
Department of Respiratory Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia.
出版信息
Med J Aust. 2003 Mar 3;178(5):214-6. doi: 10.5694/j.1326-5377.2003.tb05165.x.
Three children presented with adrenal crises, manifested by vomiting and hypoglycaemia, after protracted courses of high-dose inhaled corticosteroids for asthma. Significant dose reduction was possible in all three without loss of asthma control, emphasising the importance of back-titration to minimise dose. Parents of children taking high doses of inhaled corticosteroids should be alerted to the clinical features of adrenal insufficiency. If suspected, prompt medical assessment should be arranged, including serum glucose and cortisol measurement.
三名儿童在长期大剂量吸入皮质类固醇治疗哮喘后出现肾上腺危象，表现为呕吐和低血糖。在不影响哮喘控制的情况下，所有三名儿童都有可能大幅减少剂量，这强调了逐步减量以最小化剂量的重要性。服用高剂量吸入皮质类固醇的儿童家长应了解肾上腺功能不全的临床特征。如果怀疑有肾上腺功能不全，应安排及时的医学评估，包括测量血糖和皮质醇。
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