吸入性糖皮质激素潜在的内分泌不良反应。

Potential adverse endocrine effects of inhaled corticosteroids.

作者信息

Batch J A

机构信息

Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.

出版信息

J Paediatr Child Health. 1996 Aug;32(4):278-80. doi: 10.1111/j.1440-1754.1996.tb02552.x.

DOI:10.1111/j.1440-1754.1996.tb02552.x

PMID:8844528

Abstract

Evidence exists for a potential role for inhaled corticosteroids, particularly when used in high dose to cause growth impairment, delayed maturation and adrenal suppression in children adolescents with asthma. The functional significance of biochemical adrenal suppression remains uncertain. Similarly, there is as yet insufficient evidence to determine whether inhaled corticosteroids may adversely affect bone mineral density in children and adolescents with asthma.

摘要

有证据表明吸入性糖皮质激素可能起一定作用，尤其是高剂量使用时，会导致哮喘儿童和青少年生长发育受损、成熟延迟及肾上腺抑制。生化性肾上腺抑制的功能意义仍不明确。同样，目前尚无足够证据确定吸入性糖皮质激素是否会对哮喘儿童和青少年的骨密度产生不利影响。