Magentie H, Decoster A, Bongo R, Dehecq E, Kalach N, Kremp O, Darras A, Mulliez P, Saint Georges F
Laboratoire de microbiologie, hôpital Saint Philibert, 115 rue du Grand But, 59462 Lomme cedex.
Ann Biol Clin (Paris). 2003 Jan-Feb;61(1):106-9.
Streptococcus pneumoniae is responsible for many infectious conditions but probably with an underestimated incidence especially because of the fragility of the bacteria. The present study has evaluated a new test which detects a pneumococcal antigen in urine (Now S.p Binax). Urine samples from 181 children and 40 adults have been tested. All the patients presented with typical clinical signs of pneumococcal infection. Sensitivity = 91.7 %; specificity = 54.2 %; positive predictive value = 50 %; and negative predictive value = 92.9 % have been observed. Although the sensitivity and specificity were lower than those announced by the manufacturer, the test is easy to handle and provides a rapid argument for the diagnosis of pneumococcal infection, especially in the case of invasive infections like meningitis and bacteraemia.
肺炎链球菌可引发多种感染性疾病，但发病率可能被低估，尤其是由于该细菌较为脆弱。本研究评估了一种新的检测方法，可检测尿液中的肺炎球菌抗原（Now S.p Binax）。对181名儿童和40名成人的尿液样本进行了检测。所有患者均表现出肺炎球菌感染的典型临床症状。观察到的敏感性为91.7%；特异性为54.2%；阳性预测值为50%；阴性预测值为92.9%。尽管敏感性和特异性低于制造商公布的数据，但该检测方法操作简便，可为肺炎球菌感染的诊断提供快速依据，尤其是在脑膜炎和菌血症等侵袭性感染的情况下。
