加雷沙星（BMS-284756）及其他药物对厌氧临床分离株的活性。
Activities of garenoxacin (BMS-284756) and other agents against anaerobic clinical isolates.
作者信息
Hecht David W, Osmolski J R
机构信息
Hines VA Hospital, Hines, Illinois, USA.
出版信息
Antimicrob Agents Chemother. 2003 Mar;47(3):910-6. doi: 10.1128/AAC.47.3.910-916.2003.
A total of 590 clinical isolates consisting of 33 species of both gram-positive and gram-negative anaerobes were collected from nine centers in the Chicago area in 1998-1999. The largest number of isolates (330 isolates, 56%) belonged to the Bacteroides group. Isolates were tested by agar dilution against garenoxacin (BMS-284756, T-3811 ME), trovafloxacin, moxifloxacin, clindamycin, imipenem, piperacillin-tazobactam, and cefoxitin. All but one species (2% of Bacteroides vulgatus isolates) were fully susceptible to piperacillin-tazobactam and imipenem. A number of species were resistant to clindamycin. Among the fluoroquinolones, garenoxacin and trovafloxacin had an MIC at which 90% of the isolates tested were inhibited of <4 micro g/ml for all but two species (Fusobacterium mortiferum/varium and Peptostreptococcus anaerobius).
1998年至1999年期间，从芝加哥地区的九个中心收集了总共590株临床分离株，包括33种革兰氏阳性和革兰氏阴性厌氧菌。分离株数量最多的是拟杆菌属（330株，占56%）。采用琼脂稀释法对分离株进行加雷沙星（BMS-284756，T-3811 ME）、曲伐沙星、莫西沙星、克林霉素、亚胺培南、哌拉西林-他唑巴坦和头孢西丁的药敏试验。除一个菌种（2%的脆弱拟杆菌分离株）外，所有菌种对哌拉西林-他唑巴坦和亚胺培南均完全敏感。许多菌种对克林霉素耐药。在氟喹诺酮类药物中，加雷沙星和曲伐沙星对除两菌种（死亡/可变梭杆菌和厌氧消化链球菌）外的所有测试分离株的最低抑菌浓度（MIC）为90%时抑制浓度<4μg/ml。
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