Angenot L, Dubois M, Ginion C, van Dorsser W, Dresse A
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):246-58.
The chemical separation and identification of ten alkaloids extracted from the roots of Strychnos usambarensis are described. The elucidation of their structure by means of elementary analysis, I. R., U.V, and mass spectrometry allows their classification into bistertiary amines, hybrid and bisquaternary ammonium derivatives. This classification is reflected in the pharmacological properties. One of the tertiary amine alkaloids (usambarensine) presents atopine-like and spasmolytic activities while the bisquaternary ammonium compounds (dihydrotoxiferine, calebassine, C-curarine and afrocurarine) are competitive neuromuscular blocking agents.
本文描述了从乌干达马钱子根中提取的十种生物碱的化学分离和鉴定过程。通过元素分析、红外光谱、紫外光谱和质谱对其结构进行解析，从而将它们分类为双叔胺、杂化和双季铵衍生物。这种分类在药理特性中有所体现。其中一种叔胺生物碱（乌干达马钱子碱）具有阿托品类和抗痉挛活性，而双季铵化合物（二氢毒毛旋花子碱、加拉巴豆碱、C-箭毒碱和非洲箭毒碱）则是竞争性神经肌肉阻滞剂。
