A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids.
作者信息
Le Pera Adolfo, Leggio Antonella, Siciliano Carlo, Di Gioia Maria L, Napoli Anna, Sindona Giovanni, Liguori Angelo
机构信息
Dipartimento di Scienze Farmaceutiche, Università degli Studi della Calabria, Via P. Bucci, Cubo 15/C, I-87036 Arcavacata di Rende (CS), Italy.
出版信息
Steroids. 2003 Feb;68(2):139-42. doi: 10.1016/s0039-128x(02)00173-3.
Abstract
A facile and convenient approach to 17-ketosteroids is described. Treatment of steroids containing the C-17-dihydroxy acetone side chain with an excess of sodium methoxide in dry 1,4-dioxane under reflux, affords high yields of the corresponding 17-ketosteroids that are recovered as pure products, without the need of further purification.
摘要
Zotero 插件