Norris H J, Zirkin H J, Benson W L
Cancer. 1976 May;37(5):2359-72. doi: 10.1002/1097-0142(197605)37:5<2359::aid-cncr2820370528>3.0.co;2-q.
Fifty-eight immature ovarian teratomas were studied. Neoplams with other germ cell elements (endodermal sinus tumor, choriocarcinoma, and dysgerminoma) were excluded so that the clinical and pathologic features of "pure" immature teratomas could be defined and correlated with the prognosis. The primary tumors and their metastatic growths were graded from 0 to 3. Forty were stage I; nine, stage II; and nine, stage III. The size and stage of teratomas were related to survival, but it was the grade of the primary tumor that best determined the likelihood of extraovarian spread, and it was the grade of the metastases that related best to the subsequent course. Actuarial survival was 63% at 5 years and also at 10 years. Regardless of the grade of the primary tumor, only one of six with grade 0 metastases progressed, and that neoplasms may not have been adequately sampled. Two of five neoplasms having grade 1 metastases did not progress, and two of six patients with grade 2 metastatic growths were living after relatively long intervals. All seven patients with grade 3 metastases died with tumor, none surviving more than 2.1 years. Survival of patients with grade 1, 2, and 3 neoplasms was 81, 60, and 30% respectively. The importance of adequate sampling of primary tumor and metastases for estimating prognosis and determining therapy is stressed.
对58例未成熟卵巢畸胎瘤进行了研究。排除伴有其他生殖细胞成分的肿瘤（内胚窦瘤、绒毛膜癌和无性细胞瘤），以便能够明确“纯”未成熟畸胎瘤的临床和病理特征，并将其与预后相关联。原发肿瘤及其转移灶按0至3级分级。40例为Ⅰ期；9例为Ⅱ期；9例为Ⅲ期。畸胎瘤的大小和分期与生存率相关，但最能决定卵巢外扩散可能性的是原发肿瘤的分级，而与后续病程最相关的是转移灶的分级。5年和10年的精算生存率均为63%。无论原发肿瘤的分级如何，6例0级转移患者中只有1例病情进展，而且该肿瘤可能未得到充分取样。5例1级转移肿瘤中有2例未进展，6例2级转移瘤患者中有2例在较长时间后仍存活。7例3级转移患者均死于肿瘤，无一例存活超过2.1年。1级、2级和3级肿瘤患者的生存率分别为81%、60%和30%。强调了对原发肿瘤和转移灶进行充分取样以评估预后和确定治疗的重要性。
