Załezny Wojciech, Flisiak Robert, Prokopowicz Danuta
Klinika Obserwacyjno-Zakaźna Akademii Medycznej w Białymstoku.
Przegl Epidemiol. 2002;56(3):419-24.
The aim of the study was to evaluate relationship between clinical picture of Lyme disease and risk of Borrelia burgdorferi infection, expressed as an exposure to ticks in an endemic area of the disease.
Questionnaires regarding frequency of tick bites, symptoms of the disease in an acute phase and symptoms likely associated with previous infection were collected from 131 residents of Białowieza village, who suffered from Lyme disease in the past.
Lower prevalence of erythema migrans and significantly higher prevalence of arthritis was demonstrated in the group of persons with the highest frequency of tick bites. Evaluation of symptoms that can be related to previous Lyme disease showed significant increase of arthralgia, myalgia, ischialgia, sleep and concentration difficulties in persons with higher frequency of tick bites.
These results demonstrate, that multiple exposures to B. burgdorferi promote manifestation of the disease in the form of arthritis, and less frequently lead to the development of erythema migrans.
本研究的目的是评估莱姆病的临床表现与伯氏疏螺旋体感染风险之间的关系，该风险以在疾病流行地区接触蜱虫来表示。
从比亚沃维耶扎村131名曾患莱姆病的居民中收集了关于蜱虫叮咬频率、急性期疾病症状以及可能与既往感染相关症状的问卷。
在蜱虫叮咬频率最高的人群组中，游走性红斑的患病率较低，而关节炎的患病率显著较高。对可能与既往莱姆病相关症状的评估显示，蜱虫叮咬频率较高的人群中关节痛、肌痛、坐骨神经痛、睡眠和注意力集中困难显著增加。
这些结果表明，多次接触伯氏疏螺旋体会促使疾病以关节炎的形式表现出来，较少情况下会导致游走性红斑的发生。
