Gandini Donna
Department of Neonatology, Townsville Hospital, Townsville, Queensland, Australia.
ANZ J Surg. 2003 Mar;73(3):136-9. doi: 10.1046/j.1445-2197.2003.02574.x.
The epidemiology, microbiology and clinical management of all children under 15 years of age presenting with acute septic arthritis of the hip to Royal Darwin Hospital from July 1994 to December 1999 were reviewed and the diagnostic value of various biological markers assessed.
Systematic review was undertaken of case notes of patients identified by searching the computerized hospital patient database and the admission records for the children's ward.
Eleven cases were identified: 10 aboriginal and one caucasian. The mean temperature, white cell count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) at presentation were 39.2 degrees C, 15,500/mL, 65 mm/h and 144 mg/L, respectively. All had ESR and/or CRP >20. Plain radiographs and ultrasonography were abnormal in 1/8 and 5/6 cases, respectively. Pathogens were isolated in nine cases: Staphylococcus aureus (n = 6), Streptococcus pyogenes (n = 2) and Streptococcus pneumoniae (n = 1). Patients received intravenous antibiotics for 8.6 days (range: 3-15 days) and subsequent oral antibiotics for 22 days (range: 0-42 days). The mean (range) time from hospital admission to arthrotomy; from hospital admission to antibiotic administration; and the overall hospital stay was 23 h (range: 3-48 h); 6 h (range: 0-48 h); and 41 days (range: 6-110 days), respectively.
Elevation of temperature, white cell count, ESR and CRP were useful indicators of septic arthritis but initial diagnosis must be made on a clinical basis. Many patients had to be transferred from regional aboriginal communities and there was significant delay from onset of symptoms to arthrotomy.
对1994年7月至1999年12月间在皇家达尔文医院就诊的所有15岁以下髋关节急性化脓性关节炎患儿的流行病学、微生物学及临床管理情况进行回顾,并评估各种生物学标志物的诊断价值。
通过检索医院计算机化患者数据库及儿童病房入院记录,对确诊患者的病历进行系统回顾。
共确诊11例:10例为原住民,1例为白种人。就诊时的平均体温、白细胞计数、红细胞沉降率(ESR)及C反应蛋白(CRP)分别为39.2℃、15,500/mL、65mm/h及144mg/L。所有患者的ESR和/或CRP均>20。X线平片及超声检查分别在1/8和5/6的病例中出现异常。9例分离出病原体:金黄色葡萄球菌(n = 6)、化脓性链球菌(n = 2)及肺炎链球菌(n = 1)。患者接受静脉抗生素治疗8.6天(范围:3 - 15天),随后口服抗生素治疗22天(范围:0 - 42天)。从入院到关节切开术的平均(范围)时间;从入院到抗生素给药的时间;以及总住院时间分别为23小时(范围:3 - 48小时);6小时(范围:0 - 48小时);及41天(范围:6 - 110天)。
体温、白细胞计数、ESR及CRP升高是化脓性关节炎的有用指标,但初始诊断必须基于临床。许多患者不得不从偏远的原住民社区转诊而来,从症状出现到关节切开术有明显延迟。