Bengtson Michelle, Martin Roy, Sawrie Stephen, Gilliam Frank, Faught Edward, Morawetz Richard, Kuzniecky Ruben
Epilepsy Behav. 2000 Apr;1(2):112-119. doi: 10.1006/ebeh.2000.0051.
Previous research has suggested bilateral hippocampal support for verbal memory in women with early left-hemisphere injury and that women experience better verbal memory outcome following anterior temporal lobectomy (ATL). The present study investigated two issues: (1) Do women have better verbal memory outcome following ATL compared with men? (2) Are verbal memory abilities differentially supported by the right and left hippocampus in males and females? Verbal memory performance [Wechsler Memory Scale: Logical Memory (LM) savings score] was assessed in 70 patients who underwent ATL. MRI volumetric measurements of the left and right hippocampus were performed. No LM savings score difference was found between groups preoperatively although a statistically significant gender effect (P < 0.04) was found for postoperative LM savings scores. Females displayed better postoperative memory performance, regardless of side of surgery. Preoperative verbal memory performance was not associated with right or left hippocampal volumes in either left or right ATL females, although the right hippocampus was positively associated with memory performance for left ATL males. Hippocampal volumes were not associated with postoperative LM savings scores for any group. Results suggest that prose recall was only modestly influenced by gender and that bilateral hippocampal support for prose recall was not present in our female patients.
先前的研究表明，早期左半球损伤的女性的言语记忆得到双侧海马体的支持，并且女性在接受颞叶前切除术（ATL）后言语记忆结果更好。本研究调查了两个问题：（1）与男性相比，女性在接受ATL后是否有更好的言语记忆结果？（2）男性和女性的言语记忆能力是否受到右侧和左侧海马体的不同支持？对70名接受ATL的患者的言语记忆表现[韦氏记忆量表：逻辑记忆（LM）节省分数]进行了评估。对左侧和右侧海马体进行了MRI体积测量。术前两组之间未发现LM节省分数差异，尽管术后LM节省分数存在统计学上显著的性别效应（P < 0.04）。无论手术侧别如何，女性术后的记忆表现都更好。在接受左侧或右侧ATL的女性中，术前言语记忆表现与右侧或左侧海马体体积均无关联，尽管右侧海马体与接受左侧ATL的男性的记忆表现呈正相关。对于任何一组，海马体体积与术后LM节省分数均无关联。结果表明，散文回忆仅受到性别的适度影响，并且在我们的女性患者中不存在双侧海马体对散文回忆的支持。
