Hillaert S, Van den Bossche W
Laboratory of Pharmaceutical Chemistry and Drug Analysis, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
J Pharm Biomed Anal. 2003 Feb 26;31(2):329-39. doi: 10.1016/s0731-7085(02)00643-x.
We have investigated the capability of the capillary zone electrophoretic (CZE) and micellar electrokinetic capillary chromatographic (MEKC) methods to simultaneously separate hydrochlorothiazide and six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan mesylate, irbesartan, losartan potassium, telmisartan, and valsartan. The CZE and MEKC methods are suitable for the qualitative and quantitative determination of combined HCT/ARA-IIs in pharmaceutical formulations. Depending on the ARA-II, at least one of the two methods can be used for each combination. The two methods have been validated in terms of their linearity of response, reproducibility, and accuracy.
我们研究了毛细管区带电泳（CZE）和胶束电动毛细管色谱（MEKC）方法同时分离氢氯噻嗪和六种血管紧张素II受体拮抗剂（ARA-IIs）的能力：坎地沙坦、甲磺酸依普罗沙坦、厄贝沙坦、氯沙坦钾、替米沙坦和缬沙坦。CZE和MEKC方法适用于药物制剂中氢氯噻嗪/ARA-IIs组合的定性和定量测定。根据ARA-II的不同，两种方法中至少有一种可用于每种组合。这两种方法在响应线性、重现性和准确性方面均已得到验证。
