Ségal-Bendirdjian Evelyne, Hillion Josette, Belmokhtar Chafké Ahmed
Inserm U496, Centre G. Hayem, Hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris.
Bull Cancer. 2003 Jan;90(1):9-17.
Apoptosis is an essential physiological process that plays a critical role in development and cellular homeoastasis. This process is tightly regulated through multiple independent signalling pathways. Defects in apoptosis may contribute both to tumorigenesis and drug resistance. Understanding the molecular events that contribute to apoptosis enable a more rational approach to anticancer strategy development. These strategies will allow not only the development of new molecules targeting recently elucidated apoptotic signalling pathways, but also a better use of already kown drugs through new associations in so far as these target distinct signalling pathways.
细胞凋亡是一种重要的生理过程，在发育和细胞稳态中发挥关键作用。该过程通过多个独立的信号通路受到严格调控。细胞凋亡缺陷可能导致肿瘤发生和耐药性。了解导致细胞凋亡的分子事件有助于更合理地制定抗癌策略。这些策略不仅能开发针对最近阐明的凋亡信号通路的新分子，还能通过新的联合用药更好地利用已有的药物，因为这些药物作用于不同的信号通路。
