膳食脂肪可预测2型糖尿病患者的冠心病事件。

Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes.

作者信息

Soinio Minna, Laakso Markku, Lehto Seppo, Hakala Paula, Rönnemaa Tapani

机构信息

Department of Medicine, University of Turku, Turku, Finland.

出版信息

Diabetes Care. 2003 Mar;26(3):619-24. doi: 10.2337/diacare.26.3.619.

DOI:10.2337/diacare.26.3.619

PMID:12610011

Abstract

OBJECTIVE

To investigate whether quantity or quality of dietary fat predicts coronary heart disease (CHD) events in middle-aged type 2 diabetic subjects.

RESEARCH DESIGN AND METHODS

The dietary habits of 366 type 2 diabetic men and 295 women, aged 45-64 years and free from CHD, were assessed with a 53-item food frequency questionnaire. They were followed up for 7 years.

RESULTS

Men in the highest tertile of the polyunsaturated/saturated fat (P/S) ratio (>0.28) had a significantly lower risk for CHD death than men in the two lowest tertiles (5.0 vs. 14.2%, P = 0.009). The risk for all CHD events was 14.2 vs. 23.2%, respectively (P = 0.044). P/S ratio did not predict CHD events in women. In Cox multiple regression analyses taking into account other cardiovascular risk factors, the highest P/S ratio tertile was associated with the lowest rate of CHD death in men (P = 0.048).

CONCLUSIONS

Low P/S ratio in men predicted future CHD events in type 2 diabetic subjects independently of conventional CHD risk factors.

摘要

目的

调查膳食脂肪的量或质是否能预测中年2型糖尿病患者的冠心病（CHD）事件。

研究设计与方法

采用一份包含53个条目的食物频率问卷，对366名年龄在45 - 64岁且无冠心病的2型糖尿病男性和295名女性的饮食习惯进行评估。对他们进行了7年的随访。

结果

多不饱和/饱和脂肪（P/S）比值处于最高三分位数（>0.28）的男性，其冠心病死亡风险显著低于处于最低两个三分位数的男性（5.0%对14.2%，P = 0.009）。所有冠心病事件的风险分别为14.2%和23.2%（P = 0.044）。P/S比值不能预测女性的冠心病事件。在考虑了其他心血管危险因素的Cox多元回归分析中，最高的P/S比值三分位数与男性最低的冠心病死亡率相关（P = 0.048）。