Koppes L L J, Dekker J M, Hendriks H F J, Bouter L M, Heine R J
EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, the Netherlands.
Diabetologia. 2006 Apr;49(4):648-52. doi: 10.1007/s00125-005-0127-x. Epub 2006 Feb 4.
AIMS/HYPOTHESIS: This systematic review examines the relationship between alcohol consumption and long-term complications of type 2 diabetes. Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited.
A PubMed search through to September 2005 was performed and the reference lists of relevant articles examined. Among the relevant articles there were six cohort studies reporting on the risk of total mortality and/or fatal and/or incident CHD in alcohol non-consumers and in at least two groups of alcohol consumers.
Statistical pooling showed lower risks in alcohol consumers than in non-consumers (the reference category). The relative risk (RR) of total mortality was 0.64 (95% CI 0.49-0.82) in the <6 g/day category. In the higher alcohol consumption categories (6 to <18, and > or =18 g/day), the RRs of total mortality were not significant. Risks of fatal and total CHD were significantly lower in all three categories of alcohol consumers (<6, 6 to <18 and > or =18 g/day) than in non-consumers, with RRs ranging from 0.34 to 0.75.
CONCLUSIONS/INTERPRETATION: This meta-analysis shows that, as with findings in the general population, moderate alcohol consumption is associated with a lower risk of mortality and CHD in type 2 diabetic populations.
目的/假设：本系统评价旨在研究饮酒与2型糖尿病长期并发症之间的关系。由于关于其他并发症的文章数量有限，仅对全因死亡率、冠心病死亡率和冠心病发病率进行了荟萃分析。
检索至2005年9月的PubMed数据库，并查阅相关文章的参考文献列表。在相关文章中，有6项队列研究报告了不饮酒者以及至少两组饮酒者的全因死亡率和/或致命性和/或新发冠心病风险。
统计合并分析显示，饮酒者的风险低于不饮酒者（参照组）。每日饮酒量<6克组的全因死亡率相对风险（RR）为0.64（95%置信区间0.49 - 0.82）。在较高饮酒量组（6至<18克/天以及≥18克/天），全因死亡率的RR无统计学意义。所有三个饮酒量组（<6克/天、6至<18克/天和≥18克/天）的致命性和全因冠心病风险均显著低于不饮酒者，RR范围为0.34至0.75。
结论/解读：该荟萃分析表明，与普通人群的研究结果一致，适度饮酒与2型糖尿病患者较低的死亡率和冠心病风险相关。
