Longo Valter D, Finch Caleb E
Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA.
Science. 2003 Feb 28;299(5611):1342-6. doi: 10.1126/science.1077991.
Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.
限制热量摄入可延长多种生物体的寿命。在啮齿动物中，热量限制可降低血糖和胰岛素样生长因子I（IGF-1）水平，并延缓或减轻癌症、免疫衰老和炎症，且无不可逆的副作用。在从酵母到小鼠的各种生物体中，葡萄糖或IGF-I样信号通路的突变可延长寿命，但也会导致糖原或脂肪堆积以及侏儒症。这些信息提示了一类新的药物，这类药物能够预防或延缓衰老相关疾病，且副作用较少。
