RecQ解旋酶：基因组守护者。

RecQ helicases: caretakers of the genome.

作者信息

Hickson Ian D

机构信息

Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

出版信息

Nat Rev Cancer. 2003 Mar;3(3):169-78. doi: 10.1038/nrc1012.

DOI:10.1038/nrc1012

PMID:12612652

Abstract

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders--Bloom's syndrome--is uniquely associated with a predisposition to cancers of all types. So how do RecQ helicases protect against cancer? They seem to maintain genomic stability by functioning at the interface between DNA replication and DNA repair.

摘要

RecQ解旋酶从细菌到人类都高度保守。人类已知的五个家族成员中有三个发生种系突变会导致使人衰弱的疾病，这些疾病的特征包括易患癌症等。其中一种疾病——布卢姆综合征——与易患所有类型的癌症有着独特的关联。那么，RecQ解旋酶是如何预防癌症的呢？它们似乎通过在DNA复制和DNA修复之间的界面发挥作用来维持基因组稳定性。