Use of fluoxetine for treatment of Machado-Joseph disease: an open-label study.

CONTEXT

Machado-Joseph Disease (MJD/SCA3) is an autosomal dominant spinocerebellar degeneration that evolves to disability and death. Experimental data have shown that serotonin is an important cerebellar neurotransmitter and that impairment of the serotoninergic cerebellar system can induce cerebellar ataxia.

OBJECTIVES

To evaluate the efficacy of fluoxetine, a serotonin reuptake inhibitor, in treating neurologic dysfunction in patients with MJD.

PATIENTS AND METHODS

Thirteen MJD patients were treated with fluoxetine (20 mg/day) and were followed-up for 6 weeks. Outcome measures included functional capacity, standardized neurologic and cognitive ratings. The Montgomery-Asberg depression rating scale was used to control depressive symptoms.

RESULTS

There was no significant improvement in motor abilities after 6 weeks of treatment.

CONCLUSIONS

These results suggest that fluoxetine has no benefit in motor function of patients with MJD/SCA3.