Schönknecht Peter, Pantel Johannes, Hunt Aoife, Volkmann Martin, Buerger Katharina, Hampel Harald, Schröder Johannes
Department of Psychiatry, University of Heidelberg, Voss-Strasse 4, D-69115, Heidelberg, Germany.
Neurosci Lett. 2003 Mar 20;339(2):172-4. doi: 10.1016/s0304-3940(02)01481-7.
Cerebrospinal fluid tau protein levels are considered to be a promising marker for Alzheimer's disease (AD) and may facilitate early detection. Using the newly developed INNOTEST Phospho-Tau((181P)) kit examination of total tau and tau protein phosphorylated at threonine 181 (phospho-tau 181) revealed significantly (P<0.05) higher values in both patients with incipient and manifest AD than in controls. In patients with vascular dementia, phospho-tau 181 levels were not different from controls but were significantly lower than in patients with manifest AD. These findings suggest that total and phosphorylated tau protein may facilitate early detection and differential diagnosis of AD.
脑脊液tau蛋白水平被认为是阿尔茨海默病（AD）的一个有前景的标志物，可能有助于早期检测。使用新开发的INNOTEST磷酸化tau（（181P））试剂盒检测总tau蛋白和苏氨酸181位点磷酸化的tau蛋白（磷酸化tau 181）发现，早期和明显AD患者的这两项指标均显著（P<0.05）高于对照组。在血管性痴呆患者中，磷酸化tau 181水平与对照组无差异，但显著低于明显AD患者。这些发现表明，总tau蛋白和磷酸化tau蛋白可能有助于AD的早期检测和鉴别诊断。
