与身体接触的聚合物。
Polymers in contact with the body.
作者信息
King R N, Lyman D J
出版信息
Environ Health Perspect. 1975 Jun;11:71-4. doi: 10.1289/ehp.751171.
The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of polymeric materials is provided in order to establish a basis for the philosophy and problems encountered in assessing the acceptability of various polymers in the biological system. The requisite properties which must be demonstrated by a polymer in contact with the body are discussed from two viewpoints, i.e., the effects of the material on the stability of the host and the effects of the host on the stability of the material. In addition, the effects of synthesis, processing, storage, sterilization, implantation, and possible degradation of polymers are discussed, poly(ethylene terephthalate) being used as an example.
用于修复和恢复受损或患病组织及器官的高分子材料在临床上的应用正逐年大幅增加。与此应用相伴的是医用高分子材料相关研究的增多。本文提供了高分子材料历史和当前临床应用的信息，以便为评估各种高分子材料在生物系统中的可接受性所涉及的理念和问题奠定基础。从两个角度讨论了与人体接触的高分子材料必须具备的必要特性，即材料对宿主稳定性的影响以及宿主对材料稳定性的影响。此外，还讨论了高分子材料的合成、加工、储存、灭菌、植入以及可能的降解影响，并以聚对苯二甲酸乙二酯为例进行说明。
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